HIGHLIGHTS
- who: Kate Carroll from the Scripps Research Institute have published the research work: Wittig reagents for chemoselective sulfenic acid ligation enables global site stoichiometry analysis and redox-controlled mitochondrial targeting, in the Journal: (JOURNAL)
- what: The authors report the reaction between the ylide nucleophilic -carbon in Wittig reagents and the electrophilic -sulfur of sulfenic acid to generate a C-S bond (Fig 1c). The authors focused subsequent proteomic validation studies on WYneN. In contrast to existing mitochondrial targeting strategies that are limited to constitutive, uncontrolled delivery35, the approach provides a reaction-based switch to sequester . . .
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