Wnt/beta-catenin signalling interrupts a senescence-induction cascade in human mesenchymal stem cells that restricts their expansion

HIGHLIGHTS

• who: Johannes Lehmann from the Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC, University Medical Center, Rotterdam, The Netherlands have published the article: WNT/beta-catenin signalling interrupts a senescence-induction cascade in human mesenchymal stem cells that restricts their expansion, in the Journal: (JOURNAL)
• what: The authors show that the protein WNT3A counteracts the induction of paracrine senescence in cultured human adult mesenchymal stem cells (MSCs). In contrast to these earlier examples, the authors demonstrate here that WNT signals support MSC proliferation and developmental potential not by regulating proliferation and differentiation but . . .
  

   

  

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