Wnt/-catenin-pathway alterations and homologous recombination deficiency in cholangiocarcinoma cell lines and clinical samples: towards specific vulnerabilities

HIGHLIGHTS

  • who: Alexander Scheiter and colleagues from the Institute of Pathology, University of Regensburg, Regensburg, Germany have published the paper: Wnt/-Catenin-Pathway Alterations and Homologous Recombination Deficiency in Cholangiocarcinoma Cell Lines and Clinical Samples: Towards Specific Vulnerabilities, in the Journal: (JOURNAL)
  • what: It will be paramount to focus the analysis on HRD scores and DDR gene-related defects, given the low correlation the authors report here for CCA cell lines. This study provides a detailed overview of the mutation landscape of human CCA cell lines.
  • how: The authors analyzed CCA cell lines for . . .

     

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