Wnt signaling in the tumor microenvironment promotes immunosuppression in murine pancreatic cancer

HIGHLIGHTS

  • who: Wenting Du and collaborators from the ............................................................................................................................................................................ Department of Surgery, University of have published the research work: WNT signaling in the tumor microenvironment promotes immunosuppression in murine pancreatic cancer, in the Journal: (JOURNAL) of 27/04/2023
  • what: WNT signaling includes canonical and noncanonical pathways; the former is the focus of the work . The authors show that combination targeting reduces pancreatic cancer growth in an experimental model and might benefit the treatment of pancreatic cancer.............................................................................................................................................................................. The results showed no synergy between anti-Ly6G and Tcf7 deletion in this model (Fig S4 D), although efficient GrMDSC . . .

     

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