HIGHLIGHTS
- What: On the basis of the findings , the authors propose that another Using the organoid culture system and an animal model of RE, the study provides evidence that decreased WNT4 is responsible for increased EphB3, mislocalized Paneth cells, and excessive asymmetric crypt fission in the radiation-injured small intestine. The study demonstrated that the decreased expression of WNT4 in radiation-injuried intestinal epithelium leads to overactivation of β-catenin pathway and increase of EphB3, with EphB3 not being confined to the crypt base, but expanding upward, thus causing the misposition of Paneth cells.
- Who: Jingyang Cheng . . .
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