HIGHLIGHTS
- who: Nicholas Coupe from the University of Warwick, Coventry, UK have published the paper: WNT5A-ROR2 axis mediates VEGF dependence of BRAF mutant melanoma, in the Journal: (JOURNAL)
- what: The authors report an increased VEGF secretion in u00adBRAFMut cells, identify transmembrane receptor tyrosine kinase ROR2 and its ligand WNT5A as upregulated in u00adBRAFV600E melanomas, and show that both ROR2 and WNT5A are regulated by RAF-MEK-ERK and play a critical role in the angiogenic profile of B u00ad RAFV600E melanomas. While a difference is expected given the heterogeneity in sample biology and processing, the . . .
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