X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by hdac inhibition

HIGHLIGHTS

• who: Jonathan R. Volpatti from the Division of Genetics and Genomics, The Manton Center Harvard Medical School, Boston, MA, USA Street Institute of Child Health, University College London have published the paper: X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by HDAC inhibition, in the Journal: (JOURNAL)
• what: The authors show that VPA acts in part via modification of the XLMTM transcriptome and also via correction of defective integrin trafficking. Lastly, the authors demonstrate epigenetic abnormalities in XLMTM, changes likely driven by altered 1-carbon metabolism and that are partially improved . . .
  

   

  

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