Xnazymes targeting the sars-cov-2 genome inhibit viral infection

HIGHLIGHTS

• who: Pehuu00e9n Pereyra Gerber from the (UNIVERSITY) have published the Article: XNAzymes targeting the SARS-CoV-2 genome inhibit viral infection, in the Journal: (JOURNAL) of 22/07/2022
• what: The authors show that site-specific RNA endonuclease XNAzymes - artificial catalysts composed of single-stranded synthetic xeno-nucleic_acid oligonucleotides (in this case 2`-deoxy-2`-fluoro-u03b2-D-arabino nucleic_acid) - may be designed, synthesised and screened within days, enabling the discovery of a range of enzymes targeting SARS-CoV-2 ORF1ab, ORF7b, spike- and nucleocapsid-encoding RNA. Although the authors did not explore other modifications . . .
  

   

  

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