Yap/taz link cell mechanics to notch signalling to control epidermal stem cell fate

HIGHLIGHTS

  • who: Antonio Totaro from the Department of Molecular Medicine (DMM), University of Padua School of Medicine, viale Colombo, Padua, Italy, Department of Industrial have published the research work: YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 17/05/2017
  • what: The authors show that YAP/TAZ regulation by cell shape and rigidity of the extracellular matrix (ECM) dictates a pivotal SC decision: to remain undifferentiated and grow or to activate a terminal differentiation programme. Next, the authors aimed to determine what . . .

     

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