HIGHLIGHTS
- who: Hiroki Shimada and collaborators from the Division of Pathology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Fukumuro, Miyagino-ku, Sendai, Miyagi, Japan have published the research: YM750, an ACAT Inhibitor, Acts on Adrenocortical Cells to Inhibit Aldosterone Secretion Due to Depolarization, in the Journal: (JOURNAL)
- what: The authors demonstrated that YM750, an ACAT1 inhibitor, suppressed aldosterone synthesis, suggesting its potential as a novel therapeutic agent for PA. The results from this study showed that YM750 suppressed only KClstimulated CYP11B2 gene_expression but showed no effect on Ang II- and forskolinstimulated CYP11B2 expression. The authors . . .
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