HIGHLIGHTS
- who: Shuyao Zhang from the (UNIVERSITY) have published the research: YTHDF1 alleviates sepsis by upregulating WWP1 to induce NLRP3 ubiquitination and inhibit caspase-1-dependent pyroptosis, in the Journal: (JOURNAL) of 22/09/2021
- how: The results showed that overexpression of WWP1 induced K48-linked NLRP3 polyubiquitination in macrophages and had no significant effect on K63 ubiquitination of NLRP3 (Fig 2I). Based on the results from RT-qPCR and Western blot assay knockdown of YTHDF1 markedly downregulated the protein expression of WWP1 but had no significant effect on the RNA level of WWP1 (Fig 3E . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.