HIGHLIGHTS
- who: August and colleagues from the Anhui Medical University, China have published the paper: Z1456467176 alleviates gouty arthritis by allosterically modulating P2X7R to inhibit ammasome activation, in the Journal: (JOURNAL)
- what: The authors demonstrated that allosteric regulation of P2X7R to inhibit the NLRP3 inflammasome effectively alleviates gout inflammation, providing theoretical and data support for P2X7R as a therapeutic target for gout. The authors determined that Z1456467176 responded to different species and exerted effective inhibition of both ATP- and BzATP-induced P2X7R activation. The authors demonstrate that stimulation of MSU crystals induces an increase in ATP . . .
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