Zc3h11a loss of function enhances nf-κb signaling through defective iκbα protein expression

HIGHLIGHTS

• who: Mahmoud Darweesh and colleagues from the The Ohio State University, United States have published the article: ZC3H11A loss of function enhances NF-u03baB signaling through defective Iu03baBu03b1 protein expression, in the Journal: (JOURNAL)
• what: In this study have observed an enhanced NF-kB signaling in both ZC3-KO and ZC3-KD cells. The authors have shown that the loss of ZC3H11A protein expression resulted in upregulation of several innate and inflammatory genes (Graphical Abstract and Figures 1-3) associated with activation of the NF-kB transcription factor due to flawed IkBa mRNA export, suggesting . . .
  

   

  

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