HIGHLIGHTS
SUMMARY
Specifically, considering the cardiovascular system, zebrafish provides an excellent model for studying heart development and testing drug-induced cardiac toxicity. In fact, embryonic zebrafish can be considered for studying acute compound-induced toxicity, while adult zebrafish are used as a model for progressive and chronic diseases. IS is a small solute of 213 Da, formed by host modification of intestinal bacteria, which metabolizes the amino_acid tryptophan to indole and is then conjugated with sulfate in the liver. Hcy is a sulfur amino_acid, with a metabolism related to methionine. The Hcy hypothesis as an independent . . .
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