Zfp36l2 suppresses mtorc1 through p53-dependent pathway to prevent peripartum cardiomyopathy in mice

HIGHLIGHTS

• who: Hidemichi Kouzu and colleagues from the DepartmentNorthwestern University Pennsylvania, Philadelphia, Pennsylvania, USA have published the paper: ZFP36L2 suppresses mTORc1 through P53-dependent pathway to prevent peripartum cardiomyopathy in mice, in the Journal: (JOURNAL)
• what: The authors show that mTORc1 was activated in pregnancy to facilitate cardiac enlargement that was reversed after delivery in mice. mTORc1 activation in pregnancy was negatively regulated by the mRNAdestabilizing protein ZFP36L2 through its degradation of Mdm2 mRNA and P53 stabilization leading to increased SESN2 and REDD1 expression. Based on these results, the authors focused on the mTORc1 pathway for . . .
  

   

  

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