HIGHLIGHTS
- who: Pengchu Ju from the (UNIVERSITY) have published the research work: Zn2+ Inhibits Glycine Transport by Glycine Transporter Subtype 1b*, in the Journal: (JOURNAL) of November/14,/2003
- what: The authors have investigated the actions of Zn2ⴙ on the glycine transporters, GLYT1b and GLYT2a, expressed in Xenopus laevis oocytes and the authors demonstrate that Zn2ⴙ is a noncompetitive inhibitor of GLYT1 but has no effect on GLYT2. The study shows that mutating His-410 within ECL4 of GLYT1b, which abolishes the Zn2⫹ sensitivity, also disrupts the proton modulation (Figs 5 and 6), whereas mutating His421 . . .
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