1,25-dihydroxyvitamin d3 ameliorates lupus nephritis through inhibiting the nf-κb and mapk signalling pathways in mrl/lpr mice

HIGHLIGHTS

• who: Xuewei Li from the University, Weifang, Shandong, China have published the research work: 1,25-dihydroxyvitamin D3 ameliorates lupus nephritis through inhibiting the NF-κB and MAPK signalling pathways in MRL/lpr mice, in the Journal: (JOURNAL)
• what: The authors investigated the time-dependent effects of 1 and explored the underlying mechanism in a well-studied animal model of LN. The study showed that 1,25-dihydroxyvitamin D3 treatment ameliorates lupus nephritis in MRL/lpr mice, as shown by improved renal function, decreased immune complex deposition, reduced inflammatory cytokine production, and diminished NF-κB . . .
  

   

  

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