The circadian clock components bmal1 and rev-erbα regulate flavivirus replication

HIGHLIGHTS

• who: Xiaodong Zhuang from the University of Oxford, Oxford , QU, UK have published the paper: The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show a circadian cycling of HCV entry into hepatocytes that is defined via BMAL1 regulation of entry receptors CD81 and claudin-1. The authors show that REV-ERB overexpression or activation with synthetic agonists inhibits HCV, DENV and ZIKV RNA replication, highlighting a new role for REV-ERB to restrict RNA virus replication. The authors demonstrate that both REV . . .
  

   

  

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