Characterization of regulatory transcriptional mechanisms in hepatocyte lipotoxicity

HIGHLIGHTS

• who: Joaquín Pérez-Schindler from the University of have published the research: Characterization of regulatory transcriptional mechanisms in hepatocyte lipotoxicity, in the Journal: Scientific Reports Scientific Reports
• what: This analysis showed that repressed genes linked to CON-specific peaks were related to the regulation of cellular integrity, growth and vascularization, whereas up-regulated genes linked to NASH-specific peaks were mainly related to metabolic pathways (Fig 3I).
• how: Both human and mouse ATAC-seq data showed that the vast majority of peaks were located in introns and DNA regulatory elements such . . .
  

   

  

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