Cd5l as a promising biological therapeutic for treating sepsis

HIGHLIGHTS

• What: The authors demonstrate the utility of CD5L for treating experimental sepsis caused by cecal ligation and puncture (CLP). The authors show that CD5L`s important features include its ability to enhance neutrophil recruitment and activation by increasing circulating levels of CXCL1, and to promote neutrophil phagocytosis. The authors report that therapeutic administration of rCD5L rescues an unprecedented proportion of C57BL/6 mice from death caused by CLP or LPS, making this recombinant protein one of the most effective therapeutic agents in experimental animal models of sepsis and septic shock. Although the mechanism by which CD5L augments . . .
  

   

  

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