Influence of cluster-situated regulator ptef in filipin biosynthetic cluster on avermectin biosynthesis in streptomyces avermitilis

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  • What: The authors investigated their impact on avermectin biosynthesis and global cell metabolism. The authors investigate the influence of PteF and PteR on avermectin production in S. avermitilis S0 with two copies of ave and pte, and elucidate the cross-regulatory effect of PteF on pte and ave. The transcription level putative LacI family transcriptional regulator putative two-component system sensor kinase putative MerR family transcriptional regulator putative ArsR family transcriptional regulator To explore the effect of pteF deletion on changes in metabolic pathways, KEGG enrichment analysis was carried out to explore the global changes between sav . . .

     

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