Polymerase i as a target for treating neurodegenerative disorders

HIGHLIGHTS

• Who: Mark S. LeDoux from the Department of Psychology and College of Health Sciences, University of Memphis, Memphis, TN, USA have published the research work: Polymerase I as a Target for Treating Neurodegenerative Disorders, in the Journal: Biomedicines 2024, 1092 of /2024/

SUMMARY

Nucleolar assembly of ribosomes requires movement of ribosomal proteins, ribosomal biogenesis proteins, 5S rRNA, and snoRNAs into the nucleolus. Upstream control of the rate-limiting enzyme Pol I is an attractive therapeutic target for a number of medical disorders. The nucleolus and Pol I may be viable targets to reduce . . .

 



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