Comparative analysis of primary ovarian cancer cells and established cell lines as a new tool for studies on ovarian cancer cell complexity

HIGHLIGHTS

• What: The aim of the study was to immortalize the primary ovarian cancer (OvCa) cells using the plasmid-carrying human telomerase reverse transcriptase (hTERT) gene and compare their phenotype and biological activity with the primary cells. In the research on CSCs, CD133 is considered as a marker for the identification of CSC populations in different solid tumors, including ovarian cancer . In the study , primary and immortalized cells were determined for the activity of ALDH1, and the ALDH1 level was found to be three times higher in the obtained CD133-positive cell line OvCa7 A hTERT compared to . . .
  

   

  

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