The integrin cd11b inhibits msu-induced nlrp3 inflammasome activation in macrophages and protects mice against msu-induced joint inflammation

HIGHLIGHTS

• What: The authors demonstrate that CD11b-deficient mice developed exacerbated gouty arthritis with increased recruit‑ ment of leukocytes in the joint and higher IL-1β levels in the sera. The authors sought to evaluate the role of CD11b in NLRP3 inflammasome activation and the underlying mechanisms, and to test whether acute joint inflammation can be treated with the CD11b agonist. The authors show that lack of CD11b-mediated metabolic changes in CD11bdeficient macrophages is associated with excessive IL-1 and IL-6 production in_vitro, and with exacerbated gouty arthritis in_vivo. This study provides the first evidence that . . .
  

   

  

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