Spaceflight induces changes in gene expression profiles linked to insulin and estrogen

HIGHLIGHTS

• What: These observations lay the foundation for further studies aimed at understanding the metabolic alterations induced by spaceflight as well as highlighting insulin and estrogen signaling as potential targets for countermeasures in future spaceflight missions. According to this evidence the analysis showed inhibition of estrogen receptor signaling in the liver during spaceflight (z-score: -5.859). This could be a direct effect of spaceflight-induced physical stress as nuclear-initiated estrogen signaling (NICE) can induce corticotropin-releasing hormone CRH through the induction of ARTICLE Fig 9 Estrogen Signaling linked genes and pathways from JAXA Cell-Free Epigenome . . .
  

   

  

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