Deciphering the molecular basis of ferroportin resistance to hepcidin: structure/function analysis of rare slc40a1 missense mutations found in suspected hemochromatosis type 4 patients

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• who: M. Le Tertre et al. from the Camille-Desmoulins, Brest, France have published the Article: Deciphering the molecular basis of ferroportin resistance to hepcidin: Structure/function analysis of rare SLC40A1 missense mutations found in suspected hemochromatosis type 4 patients, in the Journal: (JOURNAL)
• what: The authors propose strategy that not limited to structure analysis but integrates information from different sources including human disease-associated and functional in vitro assays. Based on structural and mutational analyses, the authors aim to:. get insight into the interaction of hepcidin with ferroportin; characterize sequence invariants that may play . . .
  

   

  

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