Neuroprotection by adam10 inhibition requires trkb signaling in the huntington’s disease hippocampus

HIGHLIGHTS

• What: The aim of this study is to investigate the contribution of to spine pathology and LTP defects of the HD hippocampus. The authors provide evidence that active is increased in the hippocampus of two mouse models of HD leading to extensive proteolysis of N-Cadherin which has a widely recognized role in spine morphology and plasticity. The authors report that administration of the TrkB antagonist ANA12 to HD hippocampal neurons reduced the beneficial effect of GI254023X indicating that the receptor TrkB contributes to mediate the neuroprotective activity exerted by inhibition in HD. The authors demonstrate that . . .
  

   

  

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