Identification of critical residues at the c-terminal tip of ackr4 regulating chemokine internalization and βarrestin involvement

HIGHLIGHTS

• What: The authors provide evidence that fusing a C-terminal tag to ACKR4 results in pre-association of βarrestins in the absence of its ligand.
• Who: Chemokine and colleagues from the Institute of Cell Biology and Immunology Thurgau (BITG) at the University of Konstanz, Kreuzlingen CH-8280, Switzerland have published the paper: RESEARCH Open Access, in the Journal: (JOURNAL)
• How: Chemokine uptake experiments were conducted in a Hepes buffered solution containing 10 mM Hepes 145 mM NaCl 5 mM KCl 1 mM MgCl2 1 mM CaCl2 1 mM Na2HPO4 and 5 mM glucose . . .
  

   

  

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