Enhancing striatal acetylcholine facilitates dopamine release and striatal output in parkinsonian mice

HIGHLIGHTS

  • What: In this study, all data were analyzed using custom programs written in MATLAB (MathWorks, Version R2021a). The research proposes that DA-mediated inhibition of ACh release diminishes the response to L-DOPA in parkinsonian mice. The study demonstrated that local infusion of Den in the DLS failed to worsen dyskinesia induced by acute application of L-DOPA. In the study , changes in SPN activity were evaluated using calcium imaging technique , a flexible approach for characterizing various neuronal events in_vivo.
  • Who: Hongxia Li from the Animal care and usage were conducted in strict accordance with . . .

     

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