HIGHLIGHTS
- What: This study demonstrated that the proteolytic activity of hLF resides in its N-lobe by showing degradation of the IgA1 protease preprotein and Hap adhesin not only by full-length hLF, but also by a recombinant N-lobe of hLF. This analysis showed that only three Ser residues (Ser12, Ser184, and Ser283) displayed a substantial pKa-shift, resulting in strong nucleophilicity of these residues, and thus marks them as potentially interesting candidates . A lot of research has already been performed regarding the anti-adhesive properties of LF and a substantial part of this research focuses on . . .
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