A structure-based mechanism for displacement of the hexim adapter from 7sk small nuclear rna

HIGHLIGHTS

• who: Vincent V. Pham from the Harvard University have published the article: A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA, in the Journal: (JOURNAL) of 19/07/2022
• what: The authors show that HEXIM causes local destabilization of ASM4 enhancing Tat`s affinity for 7SK. The authors show that Tat capitalizes on this increased dynamic state binding to more motifs with greater affinity to the HEXIM-bound complex than to free 7SK.

SUMMARY

Received @@

ACRONYMS

LAY DEFINITIONS

• RNA . . .
  

   

  

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