HIGHLIGHTS
- who: Farid Ghorbaninezhad from the The First Hospital of Jilin University, China have published the article: CTLA-4 silencing in dendritic cells loaded with colorectal cancer cell lysate improves autologous T cell responses in vitro, in the Journal: (JOURNAL)
- what: The main reason for this is supposed to be antigen presentation weakness, diminished tumor-specific antigen expression, activation of immunosuppressive pathways, immune checkpoint signaling pathways, and presence of immune regulatory cells . The authors demonstrated that CTLA-4 silencing in CRC cell lysate-loaded DCs enhances their stimulation and leads to boosted autologous T_cells' activation and . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.