HIGHLIGHTS
- who: Alberto Caminero from the McMaster University, Hamilton L S , ON, Canada have published the article: Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors demonstrate that duodenal biopsies from patients with CeD have increased proteolytic activity against gluten peptides which correlates with Proteobacteria abundance. Using a model Proteobacterium, P. aeruginosa, which expresses the gluten-degrading protease elastase (LasB), and its isogenic nonfunctional lasB mutant19, the authors show an elastase-dependent inflammatory response mediated by the protease-activated receptor-2 . . .
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