Age at onset as an index of genetic heterogeneity in major psychiatric and substance use disorders

HIGHLIGHTS

• What: The authors investigate whether age at onset (AAO) reflects genetic heterogeneity, utilizing Genetic Risk Ratios (GRR) derived from Family Genetic Risk Scores (FGRS). For the four other primary disorders, the authors focus solely on Fig ii which presents the GRR curves. In appendix figures 1a-1e, the authors explore the impact, on the GRR profiles for the primary disorders, of censoring, from the samples , individuals with particular patterns of comorbidity. There the authors examine, for each primary disorder, the results of the GRR by AAO analyses, using a restricted range of AAOs in individuals born in . . .
  

   

  

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