Bmpr2 loss activates akt by disrupting dll4/notch1 and pparγ signaling in pulmonary arterial hypertension

HIGHLIGHTS

• What: The authors report that silencing in pulmonary artery endothelial cells (PAECs) activated AKT and suppressed the expression of DLL4. The authors demonstrate that DLL4, as expected, activated NOTCH1/N1ICD signaling but also suppressed AKT activation, while reducing cell proliferation and EndoMT in BMPR2-silenced PAECs or IPAH ECs.
• Who: Keytam S. Awad and collaborators from the Explanted human lung tissue from unused donor controls, IPAH and HPAH subjects were obtained from PHBI (see Supplementary Table , for donor information)Paraffin embedded lung tissue sections (, µm) were cut (Histoserv, Inc [, ]. Germantown, MD, USA) and slides were . . .
  

   

  

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