HIGHLIGHTS
- who: Johannes Gubat et al. from the Southern Illinois University Carbondale, United States have published the article: Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action, in the Journal: (JOURNAL)
- how: NGS data was analyzed with the MaGeCK software and by UMI lineage dropout analysis .
SUMMARY
In the previous decade, proteasome inhibitors have been successfully employed in the clinic, and agents that inhibit other UPS components are in various stages of development. b . . .
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