Defects in integrin complex formation promotechkb-mediated muscular dystrophy

HIGHLIGHTS

• What: The authors focused on the integrin-vinculintalin complex as many of its components are amphipathic proteins that exist in inactive soluble forms and are recruited to the plasma_membrane to ensure proper costamere formation. The work provides a rationale for this phenomenon in CHKB patients and Chkb-/- mice and has revealed a previously unknown link between synthesis of the major membrane phospholipid PC and PI(4,5)P2 presence at the plasma_membrane.
• Who: CHKB-mediated muscular dystrophy and collaborators from the Animal genotyping and animal ethics All animal procedures were approved by the Dalhousie University . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.