Exendin-4 blockade of t1r2/t1r3 activation improves pseudomonas aeruginosa-related pneumonia in an animal model of chemically induced diabetes

HIGHLIGHTS

• What: This study investigated whether high glucose could increase the overexpression of proinflammatory cytokines (IL-6, IL-1β, TNF-α), T1R2, T1R3, NOD1 and NF-κB p65 in PA-derived LPS-stimulated airway epithelial_cells and in the lungs of PA-infected rats with diabetes. Concurrently, the authors aimed to ascertain whether Ex-4 can mitigate the upregulation of T1R2/T1R3, the overexpression of NOD1 and NF-κB p65 and the overproduction of proinflammatory cytokines in the aforementioned models. Similarly, this study showed that, compared with those in the lungs of normal rats, the levels of proinflammatory cytokines, in . . .
  

   

  

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