HIGHLIGHTS
- who: Kaihua Zhang from the (UNIVERSITY) have published the research work: Fusion protein strategies for cryo-EM study of G protein-coupled receptors, in the Journal: (JOURNAL) of 17/Dec/2021
- what: For this approach, the authors used mouse SMO (mSMO), another GPCR with previously determined crystal and cryo-EM structures. The authors demonstrate two alternative approaches to achieve such rigidity.
- how: The study shows that only one of the two can facilitate image alignment.
SUMMARY
In GPCR crystallography, inserting a fusion_protein between transmembrane helices 5 and 6 is . . .
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