Glutathione conjugation of sesquimustard: in vitro investigation of potential biomarkers

HIGHLIGHTS

  • What: The authors aimed to identify the and conjugates of using spectrometric methods and to observe the formation of these conjugates in cell culture following exposure to different doses. Ultimately, the authors report four different conjugates of Q, which are bis-glutathionyl conjugate (GSH-ETETE-GSH), monoglutathionyl conjugate (HETETE-GSH), bis-cysteinyl conjugate (Cys-ETETE-Cys), and mono-cysteinyl conjugate (HETETE-Cys). In this study, potential biomarkers resulting from GSH conjugation that may allow the confirmation of Q exposure were investigated.
  • Who: Muharrem Cenk from the Department of, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey . . .

     

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