Glycolic acid and d-lactate—putative products of dj-1—restore neurodegeneration in fus – and sod1-als

HIGHLIGHTS

  • What: The authors show that combinatorial treatment with GA and DL restored axonal organelle deficits of mitochondria and lysosomes in FUS- and SOD1-ALS.
  • Who: Arun Pal and colleagues from the Division for Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany Dresden High Magnetic Field Laboratory (HLDEMFL), Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany Translational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany Department of Molecular Physiology and Biological Physics, University of Virginia, School of Medicine, Charlottesville, VA, USA Center for Membrane and Cell . . .

     

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