Gpcr-induced calcium transients trigger nuclear actin assembly for chromatin dynamics

HIGHLIGHTS

• who: Ying Wang from the Institute University of, Bristol , TD, UK have published the Article: GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• how: Similar results were obtained using siRNA against INF2 (Supplementary Fig 3A B).

SUMMARY

Filamentous actin structures were discovered in the nucleus when cells undergo serum stimulation, T-cell activation, DNA damage, or mitotic cell division3-5. Heterotrimeric G proteins are key components of transmembrane signal_transduction via G-protein-coupled receptors (GPCRs), controlling a plethora of vital physiological . . .

 



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