Hdac6 inhibition releases hr23b to activate proteasomes, expand the tumor immunopeptidome and amplify t-cell antimyeloma activity

HIGHLIGHTS

• What: The authors focused the studies on the HDAC6 inhibitors since these agents were among the top hits detected in the HTS and did not significantly reduce cell viability.
• Who: HDAC et al. from the Comprehensive Cancer Center, School of Medicine have published the Article: HDAC6 inhibition releases HR23B to activate proteasomes, expand the tumor immunopeptidome and 2, in the Journal: (JOURNAL) of 14/08/2024
• How: Indicated that treatment with tubastatin-A ACY-1215 and ACY-738 increased proteasome activity 50-100%. Indicated that deletion of the HDAC6-BUZ domain reduced co . . .
  

   

  

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