High interobserver variability of pten immunohistochemistry defining pten status in low- to intermediate-risk prostate cancer: results of the first german ring trial

HIGHLIGHTS

• What: As the rather poor inter-observer agreement seems unacceptable for clinical use, the authors aimed to test for a possibly improved inter-observer agreement in a subsequent second trial following feedback to the participants. In preparation of a prospective multicentric collection of molecular prostate cancer data including PTEN immunohistochemistry, a ring trial was conducted to determine the status quo of the diagnostic accuracy of PTEN immunohistochemistry in localized low- to intermediate-risk prostate cancer among ten eminent university pathology institutes in Germany. Unexpectedly, the interpretation of PTEN immunohistochemistry in this study showed marked variation (12.5 . . .
  

   

  

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