Introduction of the difluoromethyl group at the meta- or para-position of pyridines through regioselectivity switch

HIGHLIGHTS

• What: The authors demonstrate the meta-C-Hdifluoromethylation of pyridines through a radical process by using oxazino pyridine intermediates, which are easily accessed from pyridines.
• Who: Pengwei Xu from the (UNIVERSITY) have published the Article: (TITLE), in the Journal: (JOURNAL) of 16/02/2024
• How: The authors commenced the investigations with the difluoromethylation of the oxazino pyridine 3 and after extensive experimentation the authors found that the reaction is best conducted in acetonitrile in the presence of acetic acid (0.5 equiv.) and 2266-tetramethylpiperidine (TMP 2.5 equiv.) upon irradiation (LED 456 . . .
  

   

  

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