Investigation of pulmonary inflammatory responses following intratracheal instillation of and inhalation exposure to polypropylene microplastics

HIGHLIGHTS

  • What: In the present study, using polypropylene as a microplastic, the authors conducted an inhalation exposure, which is similar to the exposure route in humans, and an intratracheal instillation, which examines the potential of lung disorder by microplastics. In the inhalation exposure of this study, polypropylene fine particles were used, a low concentration of 2 mg/m3 and a high concentration of 10 mg/ m3 were set, and a short-term inhalation exposure for 4 weeks was conducted to investigate the acute effects. The authors examined the expression of chemokines that promote neutrophil migration and activation as . . .

     

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