HIGHLIGHTS
- What: The authors demonstrate that each independent pathway in every level can be efficiently optimized. The authors develop an algorithmic approach to identify the necessary nested hierarchies for the application of HOSS in any given biochemical network. To enhance the utilization of these models in biomedicine the authors propose HOSS an innovative hierarchical model optimization method. The authors show how the hierarchical approach addresses many of the challenges of parameter optimization problems, and outperforms a flat (i.e., non hierarchical single stage) optimization approach in efficiency, structure, and accuracy.
- Who: Nisha Ann Viswan et al . . .
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