Leveraging integrative toxicogenomic approach towards development of stressor-centric adverse outcome pathway networks for plastic additives

HIGHLIGHTS

• What: The authors relied on the United Nations (UN) report titled ‘Chemicals in Plastics-A Technical Report` (UNEP 2023) that cataloged chemicals found in plastics from two independent studies by Aurisano et_al (2021b) and Wiesinger et_al and identified plastic additives among them based on their reported functions. The authors propose the following five-level criterion to qualitatively understand the relevance of associations:. The authors focused on the AOP titled ‘The AOP framework on silica nanopArticles induced hepatoxicity` (AOP:463) to understand the toxicity pathway associated with DEHPinduced hepatotoxicity.
• Who: Ajaya Kumar Sahoo from the Computational . . .
  

   

  

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