HIGHLIGHTS
- who: Sungjun Beck and colleagues from the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, San Diego, La Jolla, CA, USA have published the research work: Mechanism of Action of Methotrexate Against Zika Virus, in the Journal: (JOURNAL)
- what: The authors demonstrate the antiviral activity of MTX against ZIKV and probe its mechanism of action using downstream metabolites of the DHFR pathway, leucovorin and adenosine.
- how: This study also acts as a proof-of-principal that the DFHR pathway can be targeted generally and other enzymes in . . .
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