Melanocortin 1 receptor mediates melanin production by interacting with the bbsome in primary cilia

HIGHLIGHTS

• What: The authors demonstrate a critical interplay between the primary cilium and the 1 (MC1R) signaling. The authors demonstrate significant cilium formation during the initiation of melanogenesis. The authors demonstrate that the BBSome interacts with MC1R to regulate its ciliary localization and function in melanogenesis. The authors demonstrate that enforced ciliary localization of the RHC variants elevates the melanogenesis capacity of these proteins.
• Who: Xiaoyu Tian and collaborators from the Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China, Department of . . .
  

   

  

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